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This is especially important in diabetes, where issues with insulin production or function affect glucose metabolism

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These metabolites, obtained by the activity of the microbial populations in the intestine, contribute to the health maintenance by crossing the BBB to exert antiinflammatory, antioxidant, and cognitive effects, which can help to mitigate the AD main hallmarks such as A aggregation, neuroinflammation, and synaptic loss [21, 24]

Indeed, overexpression and activation of IGF-IR is associated with high risk of metastasis and poor prognosis in many cancer patients [58]