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2.8 Statistical analyses All the data are presented as mean SEM and analysed by unpaired two-tailed Students t-test or two-way ANOVA with Bonferroni or Tukeys post-hoc test as appropriate using GraphPad Prism
keep what it needs and dispose of what it doesnt
While the oral bioavailability of aspirin is 40-50%, clinical studies indicate that the majority of aspirin's irreversible inhibition of platelet COX-1 takes place in the presystemic (portal) circulation, resulting in aspirin's antiplatelet effect being largely independent of systemic bioavailability (Pedersen & FitzGerald, 1984
Contraindications and cautions include severe gastrointestinal disease, previous pancreatitis, and severe renal impairment (depending on the specific agent)
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