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One of the more common forms of DNA damage is the deamination of the canonical nucleotide base deoxycytidine (dC) to deoxyuridine (dU)
J Biochem
This allows the product to be supplied in multi-dose vials and used for repeated withdrawals, in contrast to preservative-free sterile water which is intended for single use only
Mucoadhesive formulations can extend this residence time
158,161,164,165 However, activating multiple receptors may lead to more complex side effects, and in some experiments, dual and triple agonists have indeed shown more severe side effects
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