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*95% confidence intervals estimated using bootstrap resampling

In 2023, a randomized, double-blind, placebo-controlled, multicenter trial investigated the efficacy of tirzepatide over 24 weeks in patients with moderate-to-severe obesity and OSAS

This interaction ultimately diminishes the transcriptional activity of the NF-B complex, and as a result, SIRT1-mediated deacetylation serves to inhibit NF-B signaling