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En primer lugar, es recomendable comenzar con dosis bajas para evaluar la tolerancia individual, e ir ajustando progresivamente si fuese necesario
The Diabetes Control and Complications Trial research group previously observed that early worsening of diabetic retinopathy can occur with intensive glycemic control, though effective glycemic control ultimately lowers retinopathy risk over the long-term
Finally, polymorphisms in two genes related to the Wnt signaling pathway, Wnt-1-inducible-signaling pathway protein-1 and Wnt inhibitory factor-1, have been associated with persistent asthma
However, these can occasionally lead to inadequate nutritional intake if not properly managed
Across these systems, early clinical or translational setbacks were frequently interpreted as evidence of flawed biology rather than limitations in pharmacologic engineering, dosing paradigms, or endpoint selection
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