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Future directions The reduction of inflammation is of fundamental importance in HFpEF treatment, as CRP was associated both with cardiovascular mortality and all-cause mortality in a recent meta-analysis [56]

4-HNE is the most toxic secondary product of lipid peroxidation, and it displays a dual role as a protective signaling molecule during gene expression and a cytotoxic promoter of pathological pathways

Int J Biol Sci Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation

That complex has a half-life of many hours, but the IGF-1 it carries is not free to bind IGF1R while complexed

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