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5-HT 3 receptor antagonists seem to be effective in patients with IBS-D, a frequent adverse event is constipation, demonstrating that GI transit is effectively delayed
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440 Second, tracing the origins of resistance mechanisms remains challenging
Interestingly, inhibiting HDACs increases RB1 expression in MDSCs, halting their progression into immunosuppressive subsets and promoting their differentiation into cell types that enhance immune activity [106]
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