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While these clinical trials have shown that semaglutide can lead to significant weight loss, it is important to note that the medication is not a substitute for a healthy diet and regular exercise

The clinical data is unambiguous: researchers who try to start at maintenance doses experience significantly worse side effects without faster results

Patients with favorable GLP1R or GIPR variants often achieve excellent results on lower doses, while those with certain FTO polymorphisms may benefit from higher doses or additional metabolic support

Furihata K, Mimura H, Urva S, Oura T, Ohwaki K, Imaoka T

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