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The molecular mechanism involves Epitalon binding to chromatin regulatory regions upstream of the TERT promoter evidenced by altered histone acetylation (H3K9ac +1.3 in aged lymphocyte culture) and TERT mRNA upregulation +1.41.6 measured by RT-PCR in aged (1822-month) C57BL/6J tissue homogenates (hippocampus, bone marrow, intestinal epithelium)

Dosage: 200-500 mcg, 1-2 times daily via subcutaneous injection or daily oral capsules

Prolotherapy: Injection of dextrose or other irritant solutions triggering inflammation and healing response