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Fragment 176-191: A Speculative Role in Metabolic Research Fragment 176-191, a modified portion of an endogenously occurring peptide sequence, has been hypothesized to play a role in metabolic regulation
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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+
10.1161/01.cir.69.5.1026 19 DiplockA
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