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This binding initiates an intracellular signaling cascade, promoting gene expression related to cell survival, proliferation, and migration, ultimately leading to the formation of new capillary networks and enhanced tissue perfusion
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Additionally, they influence fibroblast behavior by enhancing proliferation, migration, and adhesion while inhibiting apoptosis-related pathways involving Bax, Bcl-2, caspase-3, and caspase-9
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