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15 Quercetin has been demonstrated to prevent neuronal injury via inhibition of oxidative stress mediated inflammation (via NLRP3 inflammasome activation) in microglia through promoting mitophagy (breakdown of mitochondria, particularly those which are dysfunctional), which provides a potential novel therapeutic strategy for neuroinflammation-related diseases
The light modifier subunit GCLM is enzymatically inactive but plays an important regulatory function by lowering the Km of GCLC for glutamate and raising the Ki for glutathione (GSH) [7, 8]
Kumar H, Sharma B
PMC 370693
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