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Some of the GLP-1s in the study have not yet been approved specifically for obesity treatment
Elevated estrogen has predictable effects on the menstrual cycle: Proliferative phase lengthens (uterine lining thickens more than usual) Breakthrough bleeding occurs if estrogen drops suddenly after a surge Next period may be heavier because the lining is thicker Estrogen can delay ovulation, shortening the luteal phase The phenomenon is well-documented in bariatric surgery literature
The local mechanisms of these effects are still under investigation, but GLP-1R co-expresses with proteins known to play an important role in appetite, such as prolactin-releasing peptide and tyrosine hydroxylase [42, 43]
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