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Within-subject variability in bioavailability was 137%, which with once-daily dosing and a long half-life translates into 33% within-subject variability in steady-state exposure

Novo Nordisk announced today promising findings from the late-stage STEP UP clinical trial demonstrating that a high-dose (7.2 mg) formulation of 1 In addition, 33.2% of those who received semaglutide 7.2 mg achieved a weight loss of 25% or more after 72 weeks, compared to 16.7% with semaglutide 2.4 mg and 0.0% with placebo

Doses were inconsistent, side effects showed up more often than expected, and in some cases, the risks were serious enough to outweigh any potential benefits

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