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High-dose oral therapy (10002000 micrograms daily) can be effective even in pernicious anaemia, as approximately 1% of B12 is absorbed through passive diffusion independent of intrinsic factor

Nicotinomide (vitamin B3) has been shown to be liver toxic in doses over 3G per day so observant of your daily and weekly intake

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However, the large number of significant correlations noted in this study between Parasutterella relative abundance and EWAT metabolites strongly supports the relevance of this genus to the EWAT metabolome