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116,117 Additionally, Smurf1 stabilizes sterol regulatory element-binding protein-1c (SREBP-1c), a key transcription factor in lipid metabolism, by preventing its ubiquitination and degradation, while BTRC promotes the proteasomal degradation of adipose triglyceride lipase
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In addition, deletion of GLS1 genes from Myc-driven liver tumors upregulates several metabolic compensatory pathways, including glycolysis and aminotransferases 111
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