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It binds to the glucagon-like peptide 1 (GLP-1) hormone and potentiates the synthesis and secretion of insulin from pancreatic -cells in a glucose-induced manner (Underwood et al., 2009)

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Second, our findings were only applicable to the studied SGLT2is (canagliflozin, dapagliflozin, and empagliflozin) and GLP1-RAs (dulaglutide and liraglutide)

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