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PMID: 17138832

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Likewise, Piezo1 modulation has emerged as an intriguing mechanotransduction lever, but existing small-molecule tools highlight unresolved issues regarding specificity, context-dependent signaling, and safety, given the roles of Piezo1 across vascular and hematologic systems, arguing against near-term clinical positioning without substantially improved pharmacological precision [328]

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Also, several studies using HCC cell lines suggested that the anticancer effect of sorafenib is attributed to ferroptosis induction via SLC7A11 inhibition (Louandre et al., 2013