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Moreover, the cardioprotective properties of GLP-1 RAs have been manifested in terms of reducing hypertension, hyperlipidemia, and cardiac arrythmias
p62 activators Two compounds able to increase p62 levels, trehalose and rapamycin, have been demonstrated to increase nuclear translocation of NRF2 in a p62-dependent manner and to enhance expression of its downstream antioxidant factors, HO1 and NQO1, in a hepatoma cellular system [308] and in a preclinical model of FRDA [309]
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Chen J, Chia N, Kalari KR, Yao JZ, Novotna M et al (2016) Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
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