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Although PF-05231023 demonstrated pharmacodynamic effects when dosed weekly or twice-weekly in humans, the unmodified N- and C-termini of the FGF21 moities resulted in a short (approximately 8 h) half-life for the intact C-terminal domain of FGF21 (183)
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Subgroup analysis according to IBS subtypes (e.g., IBS-C, IBS-D, IBS-M, and IBS-U) would have offered significant insight on how the intervention differed in its effects on these various patient groups
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