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Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC
Christou GA, Katsiki N, Blundell J, Fruhbeck G, Kiortsis DN
It is unclear why directionality would vary between studies, although we note these studies were performed in specific disease contexts, and are in substantially smaller samples
The copper ion itself serves as a cofactor for lysyl oxidase, the enzyme responsible for collagen and elastin cross-linking, meaning GHK-Cu both stimulates production of new structural proteins and ensures they are properly stabilized
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