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Tier 1: Pure GLP-1, injectable, FDA-approved Exenatide (Byetta, Bydureon) Liraglutide (Victoza, Saxenda) Lixisenatide (Adlyxin) Dulaglutide (Trulicity) Semaglutide (Ozempic, Wegovy) Efpeglenatide (Eperzan) Tier 2: Pure GLP-1, oral, FDA-approved Semaglutide (Rybelsus) Orforglipron (Orfoglip) Tier 3: Dual or triple agonist, FDA-approved Tirzepatide (Mounjaro, Zepbound) Retatrutide (Retara) Tier 4: Compounded (not FDA-approved) Compounded semaglutide Compounded tirzepatide Compounded semaglutide + B12 Compounded tirzepatide + B12 The tier system reflects regulatory status, not efficacy
People consider switching from a GLP-1 to a dual GLP-1/GIP for a few common reasons, always in consultation with their provider
A standard 100-unit insulin syringe holds 1 mL
Monitor the effects of oral medications concomitantly administered with Wegovy and make sure to discuss other medications with your providers when taking any GLP-1 medications
Topical products fall somewhere in between, depending on the manufacturer and whether the product is classified as a cosmetic or a compounded preparation
