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363 In hypoxic tumors, antagonizing HIF-1 or its transcriptional targets (e.g., PDK1/3, MT2A) may prevent mitochondrial copper sequestration and promote lethal copper accumulation

MOTS-c is encoded in mitochondrial DNA and acts largely through AMPK, the same energy-sensing pathway that exercise and caloric restriction work through

Alternatively, explore the Understanding Global Change Infographic and find new topics that are of interest and/or locally relevant to you.

Influencing the rate and spatial organisation of actin polymerisation that determines cell migration speed and directional persistence

Pickart noting hypotension as a potential concern at doses far exceeding therapeutic ranges