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The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimers disease

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Prof Adam Taylor, from Lancaster University, said potential benefits in pre-clinical studies such as those in animals and cells do not necessarily mean a peptide is beneficial for humans

Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors

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