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This biochemical action allows the lungs' natural mucociliary escalatorthe tiny hairs that sweep debris out of the airwayto clear secretions much more effectively, reducing the feeling of drowning in congestion
Coarse-grained molecular dynamics simulations reveal GLP-1R cholesterol binding sites and state-dependent cholesterol binding modes To gain insights into the precise location of cholesterol interactions with the GLP-1R, cgMD simulations were employed to study both active (corresponding to agonist bound) and inactive (apo-) states of GLP-1R in a model mammalian plasma membrane using the latest Martini 3 forcefield and cholesterol parameters (Figure 2A)
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