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Whilst research is still young in the area, its believed that microbes in our gut play a role in mediating GLP-1 production, mainly through their effect on short chain fatty acid (SCFA) production

Nausea, diarrhea, vomiting, constipation, indigestion, abdominal discomfort, fatigue, dizziness, and low blood sugar with certain diabetes medicines may occur

doi: 10.1186/s12933-022-01604-7

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At the same time, they require ongoing medical supervision, can cause side effects, and may need to be continued long-term to maintain their benefits