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Serious side effects include severe pain, persistent nausea, vomiting, diarrhea, and rectal bleeding. Coffee enemas, like taking an aspirin or any other medicine, is potentially dangerous

It also plays a role in managing reactive oxygen species (ROS), which are part of normal metabolic processes

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These findings also support our observation that BoNT/X protease causes toxicity in HEK293T cells, likely due to cleavage of additional, unidentified substrates (Supplementary Fig

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