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This mechanism leads to enhanced insulin secretion, decreased glucagon release, and slowed gastric emptyingall contributing to lower blood glucose levels and reduced appetite
Plasmid The CRE-luc vector, which contains four copies of the cyclic AMP-responsive element (CRE: TGACGTCA) was from Stratagene (La Jolla, CA, USA)
1170 HK, the enzyme that initiates glycolysis through glucose phosphorylation, is competitively inhibited by 2-deoxyglucose (2-DG), which structurally resembles glucose and binds to HK2, thereby hindering its activity through the accumulation of phosphorylated 2-DG
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