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Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)
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The shear stress medicated-mechanotransducers regulating these distinct effects are shown in Fig
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The study groups (ALC+ Clomid and Clomid alone) were each about 400 women in size, so a very reasonably powered study
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