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Most clinical research, including the most recent reviews of the literature, has demonstrated that daily doses of 500-1,500mg of berberine provide therapeutic benefits but remain well tolerated.46 12 But remember, many berberine supplements dont really contain the dose printed on the label, so the efficacy is closely tied to the brands safety measures (i.e., third-party testing and certificates of analysis)

More insights on safe usage and interactions are available

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For example, the ACOG reports that the following ingredients in acne treatments are safe to use: azelaic acid glycolic acid topical benzoyl peroxide topical salicylic acid A person might also opt for products that contain: cocoa butter aloe vera antioxidants, such as vitamin C or E shea butter coconut oil During early pregnancy, hormonal changes can worsen acne