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A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

It is approved for long-term use

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Asthma control was assessed with the ATS AQLQ

Magnetic resonance spectroscopy (MRS) in neuroinflammation MRS Can Complement PET for Studying Neuroinflammation PET is a highly sensitive neuroimaging method, capable of detecting very subtle biological changes that would be missed by other imaging modalities