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138 In a randomized placebo-controlled trial in 147 women with PCOS, L-carnitine in the form of acetyl-L-carnitine (ALC), at a dosage of 500 mg twice daily, was found to add to the benefits of the anti-diabetes medications metformin and pioglitazone (Actos)
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and avoiding blanket supplementation in patients with adequate redox balance to prevent interference with physiological ROS signaling (Sies et al., 2024
113,114 A statistical analysis of five randomized controlled trials found that cinnamon improves a measure of insulin resistance in women with PCOS
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