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Peer review Peer review information Nature Medicine thanks Henrick Imberg, Sten Madsbad, Miguel A

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They are not FDA-approved and have not gone through the review process applied to brand-name drugs

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Understanding these variants does not predict exact medication response, but reveals inherited tendencies that can support more targeted provider conversations about semaglutide, tirzepatide, or dual-compound protocols

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Even when these drugs contain the same active ingredients, they are FDA-approved for different indications

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