The initial disclosed Phase 1b data supporting the deal showed 15.1% weight loss at 12 weeks at the highest dose group against a placebo that gained 1.5% - a ~16.6 percentage-point placebo-adjusted delta in three months, which was the specific signal that triggered the transaction
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Fabbrini E, Magkos F, Mohammed BS, Pietka T, Abumrad NA, Patterson BW, Okunade A, Klein S (2009) Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Although these findings do not completely exclude the effect on kidney parenchymal cells or off-target effects, these results suggest that sulfasalazine prevents the formation of TLS not by attenuating tubular injury but via its inhibitory effect on of the cystine/glutamate transporter specifically expressed within TLS
Toxin Exposure: Chemicals, smoking, alcohol and pollution are said to lower the glutathione levels during the detoxification process