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Many are prescription-only substances listed in the poisons standard

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Research in obese rhesus macaques treated with a selective MC4R agonist for 8 weeks showed 13.5% body weight reduction, with transient decreases in food intake (35% reduction) but persistent effects on adiposity and metabolic parameters

Not reviewed by FDA for safety, efficacy, or quality

Mechanistically, GLP-1 receptors are expressed in multiple cardiovascular tissues, including the myocardium, vascular endothelium, and immune cells