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At the molecular level, repeated exposure to paracetamol and ibuprofen was associated with downregulation of TNF- and connexin 43 mRNA expression in peripheral blood, suggesting early systemic transcriptional responses accompanying the observed histological changes
Neurotox Res 1:2739 Stone JR, Yang S (2006) Hydrogen peroxide: a signaling messenger
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Nature 605 , 349356 (2022)
