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This creates a frustrating cycle where obesity perpetuates leptin resistance, which in turn makes weight management increasingly difficult
2,3 Furthermore, several cardiovascular outcome trials (CVOT) suggest GLP-1 RAs confer a mortality benefit, with significant reductions in major adverse cardiovascular events, all-cause mortality, heart failure severity, and worsening kidney function
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Several biological and lifestyle factors could be at play
We need proof that were paying for interventions that actually work
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