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JZP-458 was well tolerated in phase I clinical trials
Its use in jowls is considered off label but it is very effective in this region, and in the hands of an experienced physician it should be safe
Restoration of SLC7A11 in NRF2- or ATF4- deficient cells re-sensitizes them to glucose starvation
The dose may be reduced based on laboratory test results, after 3 to 4 weeks of therapy
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