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(PubMed) Nguyen N, Takemoto JK

Brain endothelial cells regulate glucagon-like peptide 1 entry into the brain via a receptor-mediated process

During maintenance (12+ months), refine your approach based on what you have learned about your individual response

The absolute risk increase for diabetic retinopathy complications was greater among patients with a history of diabetic retinopathy at baseline (semaglutide 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide 0.7%, placebo 0.4%)

In comparison, the subcutaneously administered once-weekly semaglutide CVOT, SUSTAIN 6 has shown superiority over placebo with a significant 26% risk reduction for MACE [19]