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One important factor influencing the efficacy of intra-articular drugs is their residence time within the joint
The underlying cause
This is helpful because it bypasses your digestive system, where B12 absorption often breaks down due to gut health issues or low stomach acid
If you have a vitamin B12 deficiency, injections are the best option because they bypass the GI tract, where the body loses some of the vitamin from oral supplements
It acts on the hypothalamus, a specific region of the brain that helps to regulate appetite and food cravings
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