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100mcg Levothyroxine will replace the low thyroid
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8 treated with 100 nmol kg 1 MK-801 ( n = 8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) for 5 days
For receptor attribution studies: MC1R-selective antagonists to isolate melanogenesis biology, MC4R-selective antagonists to isolate pro-sexual and anorectic biology, and MT-1 parallel groups to characterise the additional central effects produced by cyclisation
The fundamental difference when evaluating KLOW vs KPV lies in their intrinsic biological focuses
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