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GIP receptor activation enhances insulin secretion, modulates adipose tissue metabolism, and appears to synergise with GLP-1 activity to produce greater metabolic effects than either hormone alone as demonstrated by the clinical performance of the dual agonist tirzepatide
The cited evidence includes the patent's listing in the FDA Orange Book, August 2024 investor-call statements by Hims's CEO acknowledging that semaglutide was not going off patent, and a formal demand letter Novo sent on February 8, 2026, one day before filing
In clinical trials, people lost an average of about 15% of their body weight over 68 weeks that's about 30 pounds for someone starting at 200 pounds
This multi-modal mechanism produces both glucose control and weight lossoften 5-15 kg over 6-12 months
