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The dense ECM characteristic of osteosarcoma presents a physical barrier that restricts T cell infiltration and limits the penetration of therapeutic agents ( 3.4 Activating innate immune pathways through nanocarrier design The cGAS-STING pathway has emerged as a critical node for activating innate antitumor immunity, and its stimulation has shown promise in converting immunologically cold tumors into hot ones (56)

Japans high ergothioneine consumption is likely linked to the popularity of Shiitake and Enokitake mushrooms in Japanese society

They are also able to neutralize glutathione (10)

Methionine restriction increases blood glutathione and longevity in F344 rats

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