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10.1016/j.pmpp.2013.08.005 95 LiaoW.JiL.WangJ.ChenZ.YeM.MaH.et al
however, these trials were discontinued due to lack of efficacy [16]
Levine RL, Mosoni L, Berlett BS, Stadtman ER
Abbreviations ADT: Androgen deprivation therapy CRPC: Castration resistant prostate cancer CoQ10: Coenzyme Q10 CDK: Cyclin-dependent kinases DFO: Deferoxamine FSP1: Ferroptosis suppressor protein 1 GPX4: Glutathione peroxidase 4 GSH: Glutathione HER2: Human epidermal growth factor receptor 2 NRF2: NF-E2-related factor 2 PTEN: Phosphatase and Tensin Homolog deleted on Chromosome 10 PI3K: Phosphoinositide 3-kinase PIP3: Phosphatidylinositol (3,4,5)-triphosphate PIP2: Phosphatidylinositol (4,5)-bisphosphate ROS: Reactive oxygen species RSL3: Ras-selective lethal small molecular compound 3 VDACs: Voltage-dependent anion channels xCT: Antiporter system XC - EGFR: Epidermal Growth Factor Receptor BRAF: B-Raf proto-oncogene References Dixon SJ, et al
There is a strong connection between the gut and the skin
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