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Silencing of Sirt3 can cause adipocyte dysfunction which impairs adipogenesis and causes IR [104]
Authors perspective and future directions Current evidence supports SGLT2 inhibitors as a core component of contemporary heart failure management because of their consistent reductions in HF hospitalization and cardiovascular death across a broad range of patient populations [8,9,10,11,12,13, 45, 49]
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Despite various limitations, this preliminary study demonstrated weight increases in some patients, highlighting the need for a larger study [81]
