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.Given the correlation between PD and glucose metabolism disorders and energy conversion disorders, researchers have increasingly focused on the neuroprotective effects of GLP-1.GLP-1 receptor agonists provide neuroprotection through multiple pathways, including improving insulin sensitivity, reducing oxidative stress, and enhancing mitochondrial function, as shown in Figure 2

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Are there biomarker changes consistent with GLP-1 activation

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When the researchers factored in duration of use in secondary analyses, they did detect an increased risk of breast cancer when patients had used GLP-1 analogues for between 2.1 and 3.0 years (hazard ratio [HR] 2.7) and when the time since initiation was between 3.1 and 4.0 years (HR 2.6)

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