pharmcore semaglutide Weight Loss by Patiently |

Basu S, Riserus U, Turpeinen A, Vessby B

Lancet 402 (10400), 472483

Patients might experience challenges such as managing side effects like nausea, which can be intensified when both medications are used together

They created 3 matched cohorts: Cohort 1: Patients with obesity (without diabetes) GLP-1 users were compared with non-users (1,610 patients/group)

While GI side effects have been suggested to be involved in mediating the weight-loss effect of GLP-1RAs, analysis of large clinical trial data sets with liraglutide and semaglutide has shown that, while GI side effects may lead to more initial weight loss, they are not the mechanism of weight loss as many patients have weight loss and no side effects (182, 183)