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But results of two gold-standard trials released at the American Diabetes Associations annual meeting looked at how doses of oral semaglutide as high as 25 milligrams and 50 milligrams worked to reduce weight and improve blood sugar and other health markers

In a phase 1b trial of 72 people with type 2 diabetes, retatrutide showed a half-life of approximately 6 days, supporting once-weekly injection

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At week 56, the mean weight loss was 8.4 7.3 kg in the liraglutide group and 2.8 6.5 kg in the placebo group

Gastrointestinal side effects may increase slightly when combining medications, particularly during dose escalation of the GLP-1 agent