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3.1.1.3 Allopurinol and Nicotinamide In vitro studies show that allopurinol and nicotinamide prevent superoxide-induced growth of orbital fibroblasts in TAO patients (109)
Kidney Dysfunction: While the kidneys do not directly excrete vitamin B12 efficiently, impaired renal function may lead to elevated serum B12 levels by reducing the clearance of B12-binding proteins or altering their metabolism, thereby contributing to B12 accumulation 8
doi: 10.3390/ijms24043586 9 BalthazarC
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7:1034-1043 (2022) Acknowledgements This study was financially supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) (RS-2025-02218354) and by the R&D Program of MOTIE/KEIT (RS-2025-02307907)
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