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Joel Habener JCI .11 Jens Juul Holst 1987 1 FEBS Letters .23 1987 12, (Stephen Bloom) Lancet GLP-1(7-36) .24 GLP-1 ,

GLP-1 drugs include commonly used treatments such as semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)

In contrast to the enhancement of spontaneous excitatory postsynaptic transmission (Mietlicki-Baase et al., 2013), using retrograde labeling of VTA to nucleus accumbens (NAc) medial shell projecting neurons, in vitro patch-clamp recordings showed that exendin-4 selectively inhibits the miniature excitatory postsynaptic currents (mEPSCs) within the dopaminergic VTA-to-NAc projection neurons (Wang et al., 2015

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Ongoing Research and Areas for Future Study Although research on using semaglutide and lipotropic injections together is limited, scientists are beginning to explore combined treatments for weight loss